Implanted, intracardiac device design – The performance and reliability of devices such as catheters, pacing leads, coronary stents, replacement valves, ventricular assist and other medical devices that are implanted in the heart or circulation for either short or long duration is a major concern of medical device designers and manufacturers, clinicians and FDA. Insilicomed’s software tools that can simulate the performance of new device designs in the environment of the intact heart allow engineers to perform computational tests before building expensive prototypes and conducting animal studies.
Our simulations can also be used to guide animal testing and to correlate such tests with them to improve the accuracy of simulations results. Thereafter, parametric studies can be performed to visualize and understand how changes in device parameters affect cardiac function. Plus Insilicomed’s detailed patient-specific simulations of cardiac disease states such as myocardial infarction, heart failure and others can be used to analyze how implants perform under wide-ranging biologic conditions observed in heart disease.
Computational analysis of cardiac images – As new cardiac imaging technologies such as three-dimensional echocardiography, speckle tracking, cardiac MRI and delayed contrast cardiac CT emerge, a major problem facing clinicians and vendors is less the quality and information content of the images, but rather the interpretation of the increasingly large volumes of complex dynamic three-dimensional data. The next generation of imaging systems will include software that aids the clinical interpretation of the images by building in known properties of the tissues and organs being imaged to derive more fundamental and reliable clinical information. Insilicomed’s cardiac computational models are the most realistic simulations of electrical and mechanical heart function making them unique and ideal for these purposes, taking disparate clinical data such as cardiac images and other clinical measures and integrating them in realistic heart simulations.
Computer-assisted surgery – Surgical device manufacturers are increasingly interested in smart devices such as surgical robots that improve the accuracy and precision of surgical procedures, make use of radiographic data acquired prior to surgery, and minimize the duration and invasiveness of surgery. Behind these new techniques will be Insilicomed’s software technology that can faithfully mimic the anatomical and physiologic properties of human tissues and organs.
Drug Discovery – Many disease conditions, especially heart diseases, involve complex interactions between networks of molecules, cells and organs. Although drugs target a specific molecule, their efficacy is unpredictable and requires extensive animal testing. By simulating the function of the normal and diseased heart from cell to organ, Insilicomed’s software platform will help pharmaceutical companies screen candidate therapies. For the first time, medical therapy can be tested in terms of its effect on cells, organs and patients.